3-Chloropropyldimethylphosphine oxide → [3-(3,7-Dimethylxanthin-1-yl)propyl]dimethylphosphine Oxide

反応式

[Na].[CH3:2][N:3]1[C:11]2[N:10]=[CH:9][N:8]([CH3:12])[C:7]=2[C:6](=[O:13])[NH:5][C:4]1=[O:14].Cl[CH2:16][CH2:17][CH2:18][P:19](=[O:22])([CH3:21])[CH3:20]>>[CH3:2][N:3]1[C:11]2[N:10]=[CH:9][N:8]([CH3:12])[C:7]=2[C:6](=[O:13])[N:5]([CH2:16][CH2:17][CH2:18][P:19](=[O:22])([CH3:21])[CH3:20])[C:4]1=[O:14]

参加物

反応物 2

HCID 126691413-Chloropropyldimethylphosphine oxide

HCID 66980828Theobromine sodium

生成物 1

HCID 19689284[3-(3,7-Dimethylxanthin-1-yl)propyl]dimethylphosphine Oxide

実験手順

The title substance was prepared from 10.1 g (0.05 mol) of 3,7-di-methylxanthine sodium salt and 3-chloropropyldimethylphosphine oxide analogously to Example 59 and crystallized from ethyl acetate.

後処理

customcrystallized from ethyl acetate

出典と根拠

ORDレコード: ord-8bac5cbac8e5458191432b2c76a6fd1b
出典データセット: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05728686

反応ノート

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