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Methyl 3-(benzyloxy)-5-[4-(methanesulfonyl)phenoxy]benzoate → Methyl 3-hydroxy-5-(4-(methylsulfonyl)phenoxy)benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 3-(benzyloxy)-5-[4-(methanesulfonyl)phenoxy]benzoate | HCID 53393370 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Methyl 3-hydroxy-5-(4-(methylsulfonyl)phenoxy)benzoate | HCID 46941846 | 100.4% |
反応手順
Methyl 3-(phenylmethyl)oxy-5-[4-(methylsulfonyl)phenoxy]benzoate (3.50 g, 8.50 mmol) was dissolved in THF (60 mL) followed by 10% palladium on carbon (500 mg). The reaction was then placed under a hydrogen atmosphere by an evacuation-backfill technique. The reaction was then stirred vigorously for 4 h followed by filtration and evaporation which afforded the title compound as an colourless oil (2.75 g, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745475B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-7bc23264b96942be9c3b1ccb95e8e4d8 |
| 出典メモ | uspto-grants-2010_06 |