Ethanone, 2-chloro-1,2-diphenyl- → 2-(3,4-Methylenedioxyphenyl)-4,5-diphenylthiazole

HRID 2049275

反応式

HRID 2049275 の反応式
[C:1]([NH2:12])(=[S:11])[C:2]1[CH:10]=[CH:9][C:8]2[O:7][CH2:6][O:5][C:4]=2[CH:3]=1.[C:13]1([C:19]([CH:21](Cl)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=O)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(O)C>[CH2:6]1[O:7][C:8]2[CH:9]=[CH:10][C:2]([C:1]3[S:11][C:19]([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)=[C:21]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[N:12]=3)=[CH:3][C:4]=2[O:5]1

参加物

4

反応物 2

HCID 95343Ethanone, 2-chloro-1,2-diphenyl-HCID 27761262H-1,3-benzodioxole-5-carbothioamide

生成物 1

HCID 203449832-(3,4-Methylenedioxyphenyl)-4,5-diphenylthiazole収率 67.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Thiopiperonylamide (18.1 g, 0.10 mole) and desyl chloride (23.1 g, 0.10 mole) are heated under reflux in 95% ethanol (100 ml) for two hours. An oil precipitates which solidifies when the reaction mixture is cooled. The solid is collected and recrystallized from ethanolethyl acetate to give 24.0 g (67% yield ) of 2-(3,4-methylenedioxyphenyl)-4,5-diphenylthiazole, m.p. 121°-124° C. Thiopiperonylamide is also prepared from the corresponding nitrile by the method of Fairfull et al., J. Chem. Soc. 1952, 742.

後処理

  1. customAn oil precipitates which
  2. temperatureis cooled
  3. customThe solid is collected
  4. customrecrystallized from ethanolethyl acetate

出典と根拠

ORDレコード
ord-52f6e35e790d48d48e59f5d026142358
出典データセット
uspto-grants-1980_04
特許番号
US04197306

関連ノート

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