Sodium Cyanide → HCID 20344097、化合物

HRID 2049631ノート

反応式

HRID 2049631 の反応式
Cl[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=1.[C-:17]#[N:18].[Na+]>C(O)C.O>[F:16][C:12]1[CH:11]=[C:10]([CH:15]=[CH:14][CH:13]=1)[O:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[CH2:2][C:17]#[N:18]

参加物

5

反応物 2

HCID 8929Sodium CyanideHCID 20344102HCID 20344102、化合物

生成物 1

HCID 20344097HCID 20344097、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

1-(Chloromethyl)-2-(3-fluorophenoxy)benzene (26.5 g.) was dissolved in 300 ml of ethanol; a solution of sodium cyanide (7.8 g.) in 15 ml of water was added, and the resulting mixture was heated to reflux overnight. The ethanol was evaporated, the residue taken up in water, extracted with ether and the combined ether extracts were dried and concentrated to give the title compound. ##STR13##

後処理

  1. temperaturethe resulting mixture was heated
  2. temperatureto reflux overnight
  3. customThe ethanol was evaporated
  4. extractionextracted with ether
  5. dry with materialthe combined ether extracts were dried
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-80b7f065ce434db98481f731fca32278
出典データセット
uspto-grants-1980_04
特許番号
US04198421

反応ノート

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