HCID 20344091、化合物 → HCID 20344093、化合物

HRID 2049633ノート

反応式

HRID 2049633 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][C:13]([OH:15])=O>O>[F:1][C:2]1[CH:18]=[CH:17][C:16]2[C:13](=[O:15])[CH2:12][C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=3[O:5][C:4]=2[CH:3]=1

参加物

3

反応物 1

HCID 20344091HCID 20344091、化合物

生成物 1

HCID 20344093HCID 20344093、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2-(3-Fluorophenoxy)benzeneacetic acid (22 g.) was added to 90 g. of polyphosphoric acid at 125°. The reaction mixture was stirred 1 hour at 125°. It was then cooled; water (300 ml) was added with stirring; a solid product was filtered and extracted with toluene several times. The combined toluene extracts were washed successively with water, dilute alkali, and water, then dried over magnesium sulfate and evaporated to yield the title compound as a solid product, which was purified upon treatment with hexane. ##STR15##

後処理

  1. customat 125°
  2. temperatureIt was then cooled
  3. stirringwith stirring
  4. filtrationa solid product was filtered
  5. extractionextracted with toluene several times
  6. washThe combined toluene extracts were washed successively with water
  7. additiondilute alkali, and water
  8. dry with materialdried over magnesium sulfate
  9. customevaporated

出典と根拠

ORDレコード
ord-345b32881f654435a82c1ffd1be7e4fd
出典データセット
uspto-grants-1980_04
特許番号
US04198421

反応ノート

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