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Water → 1-(3-Methoxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 反応物 | 1-(3-Methoxyphenyl)-2-(1-methyl-2-pyrrolidinyliden)ethanone | HCID 57153745 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-(3-Methoxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone | HCID 20344142 | — |
反応手順
11.8 g of lithium aluminum hydride are added portionwise at 0° with stirring to 144.8 g of 1-(3-methoxyphenyl)-2-(1-methyl-2-pyrrolidinyliden)ethanone dissolved in 1.4 liters of tetrahydrofuran. 30 minutes after completion of the addition, 300 ml of water are cautiously added dropwise, with cooling; then 800 ml of diethyl ether are added, and the organic phase is collected. The organic phase is dried over sodium sulfate, the solvent is removed by evaporation, and the oily residue is distilled under a vacuum to obtain 127 g (87% of theory) of the title compound:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04198424 |
| 出典データセット | uspto-grants-1980_04 |
| ORD ID | ord-7820fc9e1cab48449fbfec1eb3cd7a56 |
| 出典メモ | uspto-grants-1980_04 |