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Hydrogen Bromide → 1-(3-Hydroxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | 1-(3-Methoxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone | HCID 20344142 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 1-(3-Hydroxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone | HCID 20344140 | — |
反応手順
40.5 of 1-(3-methoxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone are boiled under reflux for 6 hours with 180 ml of acetic acid and 180 ml of 47% hydrobromic acid. After concentration of the solution, the oily residue is brought to crystallization through treatment with 150 ml of hot ethanol. Cooling is allowed to take place, and 39.8 g (76% of theory) of the hydrobromide of the title compound is filtered off as greenish crystals: m.p. 165° to 168°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04198424 |
| 出典データセット | uspto-grants-1980_04 |
| ORD ID | ord-de4b1731d35c4d0a8b1e8f23c53058e2 |
| 出典メモ | uspto-grants-1980_04 |