Flufenamic Acid → Ufenamate

HRID 2049693

反応式

HRID 2049693 の反応式
[K].[F:2][C:3]([F:21])([F:20])[C:4]1[CH:5]=[C:6]([NH:10][C:11]2[C:12](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:13]([OH:15])=[O:14])[CH:7]=[CH:8][CH:9]=1.[CH2:22](Br)[CH2:23][CH2:24][CH3:25]>CN(C)C=O>[F:2][C:3]([F:20])([F:21])[C:4]1[CH:5]=[C:6]([NH:10][C:11]2[C:12](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:13]([O:15][CH2:22][CH2:23][CH2:24][CH3:25])=[O:14])[CH:7]=[CH:8][CH:9]=1

参加物

5

反応物 3

HCID 3371Flufenamic AcidHCID 8002Butyl bromideHCID 5462222Potassium

生成物 1

HCID 5632Ufenamate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

In anhydrous dimethyl formamide was dissolved 3.2 g. of potassium salt of N-(3-trifluoromethylphenyl)anthranilic acid. To the solution was added 5.0 g. of n-butyl bromide. The mixture was heated at 100°-120° C. for 5 hrs. while stirring. The precipitated potassium bromide was taken out by filtration. The filtrate was concentrated and the residue obtained was distilled to obtain 3.1 g. of light yellow liquid having a boiling point of 190°-192° C. (5 mmHg).

後処理

  1. additionTo the solution was added 5.0 g
  2. temperatureThe mixture was heated at 100°-120° C. for 5 hrs
  3. filtrationThe precipitated potassium bromide was taken out by filtration
  4. concentrationThe filtrate was concentrated
  5. customthe residue obtained
  6. distillationwas distilled
  7. customto obtain 3.1 g

出典と根拠

ORDレコード
ord-c354eda409e54bc2b52759f93ba028d1
出典データセット
uspto-grants-1980_04
特許番号
US04198431

関連ノート

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