関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Phosphinic Acid | HCID 4124402 | — |
| 反応物 | 2-Hydroxy-2-(4-hydroxyphenyl)acetic acid, sodium salt hydrate | HCID 23698133 | — |
| 反応物 | HCID 178527018 | HCID 178527018 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Hydroxyphenylacetic acid | HCID 127 | 67% |
反応手順
A stirred mixture of sodium p-hydroxymandelate monohydrate (21.2 g.), potassium hypophosphite (52 g.), 50% w/v aqueous hypophosphorous acid (2.2. ml.) and water (10 ml.) is heated under reflux for 22 hours (internal temperature 143° C.) and then cooled. The mixture is diluted with water, acidified with hydrochloric acid and extracted with methyl isobutyl ketone. p-Hydroxyphenylacetic acid, which is formed in 67% yield, is isolated from the extract by conventional means.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04198526 |
|---|
| 出典データセット | uspto-grants-1980_04 |
|---|
| ORD ID | ord-e5a7f46740e04d07bec40324c7d375f1 |
|---|
| 出典メモ | uspto-grants-1980_04 |
|---|
