Potassium Hydroxide → 3-(4-Chlorophenoxy)-2,2-dimethylcyclopropanecarboxylic acid

HRID 2049819ノート

反応式

HRID 2049819 の反応式
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][CH:7]2[CH:9]([C:10]([O:12]CC)=[O:11])[C:8]2([CH3:16])[CH3:15])=[CH:4][CH:3]=1.[OH-].[K+]>O.C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH:7]2[CH:9]([C:10]([OH:12])=[O:11])[C:8]2([CH3:15])[CH3:16])=[CH:17][CH:18]=1

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 20344552Ethyl 3-(4-chlorophenoxy)-2,2-dimethylcyclopropanecarboxylate

生成物 1

HCID 203049613-(4-Chlorophenoxy)-2,2-dimethylcyclopropanecarboxylic acid

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

The ethyl 3-(4-chlorophenoxy)-2,2-dimethylcyclopropanecarboxylate (l.5 g) is hydrolyzed by heating under reflux with 10% potassium hydroxide in a mixture of 20% water and 80% ethyl alcohol for 1 hr and letting stand at 25° overnight. The solution is cooled and solvent is removed in vacuo. The residue is diluted with water and extracted with ether. The aqueous phase is then acidified with aqueous HCl and extracted with ether. The organic phase is washed with water and brine, dried over sodium sulfate and the solvent removed in vacuo to give 3-(4-chlorophenoxy)-2,2-dimethylcyclopropanecarboxylic acid.

後処理

  1. temperatureby heating
  2. customat 25°
  3. customovernight
  4. temperatureThe solution is cooled
  5. customsolvent is removed in vacuo
  6. additionThe residue is diluted with water
  7. extractionextracted with ether
  8. extractionextracted with ether
  9. washThe organic phase is washed with water and brine
  10. dry with materialdried over sodium sulfate
  11. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-5310d75bd8364f5e910f78e7533fafaa
出典データセット
uspto-grants-1980_04
特許番号
US04198527

反応ノート

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