Hydrochloric Acid → 4-(Chloromethyl)benzophenone

HRID 2049904

反応式

HRID 2049904 の反応式
C[C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].ClCl.[ClH:18].[CH:19](O)(C)C>>[Cl:18][CH2:19][C:14]1[CH:15]=[CH:2][C:3]([C:4]([C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=2)=[O:5])=[CH:12][CH:13]=1

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 24526Chlorine2 回HCID 672302-Methylbenzophenone

生成物 1

HCID 30163764-(Chloromethyl)benzophenone収率 57%

実験手順

The amount of 912 grams (4.65 moles) of methyl benzophenone was then melted and heated to 100°-110° C. in a two-liter, two-necked, round bottom flask with magnetic stirring. Chlorine gas was introduced through a gas dispersion tube immersed below the liquid at a rate such that the characteristic greenish color of chlorine was not detectable in the exiting stream of hydrogen chloride. Initially the reaction was exothermic and no additional external heating was required. After about seven hours the theoretical uptake in weight (160 g) had occured. The hot melt was poured into 6 liters of isopropyl alcohol. This mixture was chilled to -5° to 0° C. and the precipitated solid was removed by suction filtration to provide 618 grams (57% yield) of 4-(chloromethyl)benzophenone, mp 109°-111° C. A carbonyl band at 1670 cm-1 was noted in the infrared spectrum.

後処理

  1. temperatureheated to 100°-110° C. in a two-liter
  2. temperatureno additional external heating
  3. temperatureThis mixture was chilled to -5° to 0° C.
  4. customthe precipitated solid was removed by suction filtration

出典と根拠

ORDレコード
ord-dde9ee2b13594739af835b2403a2a649
出典データセット
uspto-grants-1980_04
特許番号
US04199420

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