Propargyl bromide → Propargyl 2-chloro-4-trifluoromethyl-5-thiazolecarboxylate

HRID 2049935ノート

反応式

HRID 2049935 の反応式
[Cl:1][C:2]1[S:3][C:4]([C:11]([OH:13])=[O:12])=[C:5]([C:7]([F:10])([F:9])[F:8])[N:6]=1.[CH2:14](Br)[C:15]#[CH:16].C(NC(C)C)(C)C>C(Cl)Cl>[Cl:1][C:2]1[S:3][C:4]([C:11]([O:13][CH2:16][C:15]#[CH:14])=[O:12])=[C:5]([C:7]([F:8])([F:10])[F:9])[N:6]=1

参加物

5

反応物 3

HCID 7842Propargyl bromideHCID 7912DiisopropylamineHCID 132827432-Chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid

生成物 1

HCID 13670344Propargyl 2-chloro-4-trifluoromethyl-5-thiazolecarboxylate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 4.63 g (0.02 mole) of 2-chloro-4-trifluoromethyl-5-thiazolecarboxylic acid, 2.42 g (0.02 mole) of propargyl bromide, 2.59 g (0.02 mole) of diisopropylamine, and 50 ml. of methylene chloride was stirred for 16 hours. The methylene chloride solution was washed successively with diluted hydrochloric acid and saturated sodium bicarbonate, dried (MgSO4) and concentrated under reduced pressure. The residue was Kugelrohr distilled to give propargyl 2-chloro-4-trifluoromethyl-5-thiazolecarboxylate as a colorless liquid.

後処理

  1. washThe methylene chloride solution was washed successively with diluted hydrochloric acid and saturated sodium bicarbonate
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated under reduced pressure
  4. distillationdistilled

出典と根拠

ORDレコード
ord-098da4297a1c4727a0d64efee7c7516d
出典データセット
uspto-grants-1980_04
特許番号
US04199506

反応ノート

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