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Oxygen → methyl (13S,15R,16R,18S)-13-[(1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-17-oxa-1,11-diazapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Oxygen | HCID 977 | — |
| 反応物 | Azobisisobutyronitrile | HCID 6547 | — |
| 反応物 | 3',4'-Anhydrovinblastine | HCID 443324 | — |
| 生成物 | methyl (13S,15R,16R,18S)-13-[(1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-17-oxa-1,11-diazapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate | HCID 442111 | — |
反応手順
100 mg. of 3',4'-anhydro-vinblastine are oxidized with oxygen from the air in an analogeous manner to that set forth in the Example 16, with the only difference that the reaction is performed in the presence of 4 mg. of 2,2'-azo-bis-isobutyronitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04199505 |
| 出典データセット | uspto-grants-1980_04 |
| ORD ID | ord-0a9c4345ddb34fb9a86b994ba2507151 |
| 出典メモ | uspto-grants-1980_04 |