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Hydrochloric Acid → 2-Hydroxy-2-(1-benzylpyrrolidin-3-yl)acetonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 1-Benzylpyrrolidine-3-carbaldehyde | HCID 4589478 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Hydroxy-2-(1-benzylpyrrolidin-3-yl)acetonitrile | HCID 20342257 | 84.7% |
反応手順
To a solution of 12.45 g of crude 1-benzyl-3-formylpyrrolidine in a mixture of 23 ml of tetrahydrofuran and 23 ml of water is added 11.4 ml (2 equivalents) of concentrated hydrochloric acid and then 8.39 g (2 equivalents) of potassium cyanide powder in a period of 15 minutes under ice-cooling. The mixture is stirred at the same temperature for 2 hours, adjusted to pH 10 with 10% aqueous sodium carbonate solution, and extracted thrice with methylene chloride. The extract is washed with water, dried over sodium sulfate and evaporated under reduced pressure to yield 12.05 g of 2-hydroxy-2-(1-benzylpyrrolidin-3-yl) acetonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04200628 |
| 出典データセット | uspto-grants-1980_04 |
| ORD ID | ord-5299a62f2b5842b290a5b4acde50e4c2 |
| 出典メモ | uspto-grants-1980_04 |