1,4-Dibromobutane → [4-(1-Adamantyloxy)-2,6-dimethylphenyl]pyrrolidine

HRID 2050221ノート

反応式

HRID 2050221 の反応式
[C:1]12([O:11][C:12]3[CH:18]=[C:17]([CH3:19])[C:15]([NH2:16])=[C:14]([CH3:20])[CH:13]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.Br[CH2:22][CH2:23][CH2:24][CH2:25]Br.C([O-])([O-])=O.[K+].[K+]>C(O)C>[C:1]12([O:11][C:12]3[CH:13]=[C:14]([CH3:20])[C:15]([N:16]4[CH2:25][CH2:24][CH2:23][CH2:22]4)=[C:17]([CH3:19])[CH:18]=3)[CH2:2][CH:3]3[CH2:9][CH:7]([CH2:6][CH:5]([CH2:4]3)[CH2:10]1)[CH2:8]2

参加物

5

反応物 3

HCID 80561,4-DibromobutaneHCID 11430Potassium CarbonateHCID 125102894-(1-Adamantyloxy)-2,6-dimethylaniline

生成物 1

HCID 12510315[4-(1-Adamantyloxy)-2,6-dimethylphenyl]pyrrolidine収率 111.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 1.8 g (6.63 mmoles) of 4-(1-adamantyloxy)-2,6-dimethylaniline, 1.43 g (6.63 mmoles) of 1,4-dibromobutane, and 2.01 g (14.6 mmoles) of K2CO3 in 25 ml deaerated absolute ethanol is refluxed for forty-five hours, cooled, and evaporated. The residue is taken up in CH2Cl2 (125 ml) and water (125 ml). The CH2Cl2 layer is washed with water, and the combined aqueous layers are extracted with CH2Cl2 (50 ml.). The combined organic layers are dried and concentrated to give 2.4 g of a brown oil, which is chromatographed by HPLC on a 2.54 cm×109 cm column at 40 psi eluting with 0.5% acetone in CH2Cl2 and then 0.75% acetone in CH2Cl2 to give 0.45 g in the first liter eluted from the column. This solid in 1 ml of CH2Cl 2 and 5 ml of ether is treated with 3.5 N HCl in ether. The hydrochloride is filtered, washed with ether, and dried to give 0.38 g of white solid, m.p. 184.4-185.6 (dec.).

後処理

  1. temperatureis refluxed for forty-five hours
  2. temperaturecooled
  3. customevaporated
  4. washThe CH2Cl2 layer is washed with water
  5. extractionthe combined aqueous layers are extracted with CH2Cl2 (50 ml.)
  6. customThe combined organic layers are dried
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-97272d30e3964158b4741a9f242916d4
出典データセット
uspto-grants-1980_04
特許番号
US04200588

反応ノート

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