Sodium Cyanide → Cyano(2,4-dioxo-1-propargyl-3-imidazolidinyl)methanol
反応式
[O:1]=[C:2]1[N:6]([CH:7]=[O:8])[C:5](=[O:9])[CH2:4][N:3]1[CH2:10][C:11]#[CH:12].[C-:13]#[N:14].[Na+].S(=O)(O)[O-].[Na+]>CCOCC.O>[C:13]([CH:7]([N:6]1[C:5](=[O:9])[CH2:4][N:3]([CH2:10][C:11]#[CH:12])[C:2]1=[O:1])[OH:8])#[N:14]参加物
6
実験手順
To a solution of 2,4-dioxo-1-propargyl-3-imidazolidine-carbaldehyde (1.8 mmol) in 25 ml of ether is added 25 ml of water followed by sodium cyanide (3.04 mmol). The mixture is stirred vigorously while a solution of sodium bisulfite (2.45 mmol) in 15 ml of water is added over about 5 minutes. The reaction mixture is stirred for two hours. The organic phase is separated, washed with water, dried over calcium sulfate and solvent evaporated to give cyano(2,4-dioxo-1-propargyl-3-imidazolidinyl)methanol.
後処理
- additionis added over about 5 minutes
- customThe organic phase is separated
- washwashed with water
- dry with materialdried over calcium sulfate and solvent
- customevaporated
出典と根拠
- ORDレコード
- ord-bd696feb11a6475790143d41b9c225f4
- 出典データセット
- uspto-grants-1980_04
- 特許番号
- US04200758
反応ノート
読み込み中…