HCID 19380545、化合物 → HCID 178513639、化合物

HRID 2050431ノート

反応式

HRID 2050431 の反応式
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[CH2:6][CH:7]=[C:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:22]=[CH:21][C:17]([C:18]([NH2:20])=[O:19])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1>[Pt].C.O1CCOCC1.C(N(CC)CC)C>[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[CH2:6][CH2:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([C:14]2[CH:15]=[CH:16][C:17]([C:18]([NH2:20])=[O:19])=[CH:21][CH:22]=2)[CH2:10][CH2:9]1

参加物

4

反応物 1

HCID 19380545HCID 19380545、化合物

生成物 1

HCID 178513639HCID 178513639、化合物収率 45.7%

試薬・触媒・溶媒 2

HCID 16218561HCID 16218561、化合物触媒HCID 68453242Dioxan triethylamine溶媒

実験手順

A mixture of 500 mg of 4-[4-[2-(1,3-dioxolan-2-yl)ethylidene]cyclohexyl]benzamide and 20 ml of dioxan/triethylamine (vol. 9:1) was hydrogenated in the presence of 500 mg of 10 percent platinum-charcoal for 2 hours. The reaction mixture was then filtered and the filtrate was evaporated. Recrystallization of the evaporation residue from 40 ml of dioxan gave 230 mg of 4-[trans-4-[2-(1,3-dioxolan-2-yl)ethyl]cyclohexyl]benzamide as colorless crystals.

後処理

  1. filtrationThe reaction mixture was then filtered
  2. customthe filtrate was evaporated
  3. customRecrystallization of the evaporation residue from 40 ml of dioxan

出典と根拠

ORDレコード
ord-f990f42e8bff4699a1bc38b023b90f57
出典データセット
uspto-grants-1991_05
特許番号
US05013477

反応ノート

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