化工社化工社 化学情報印刷レポート · 研究参考用
Methyl propiolate → methyl (E)-3-[4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-yl]-2-propenoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl propiolate | HCID 13536 | — |
| 反応物 | 4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazole | HCID 14849776 | — |
| 生成物 | methyl (E)-3-[4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-yl]-2-propenoate | HCID 14849778 | 46.6% |
反応手順
From 4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazole (2.00 g) and methyl propiolate (2.55 g) by the process as described for the preparation of Intermediate (7 a) to afford an orange solid which was purified by FCC eluting with System A (3:17) to afford the title compound (1.194 g) as a white solid. λmax (MeOH) 248.4 (22,180) and 300 (inf) nm (ε9410).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05013749 |
| 出典データセット | uspto-grants-1991_05 |
| ORD ID | ord-55f9218a62e54a6ab4ee821c4adb871a |
| 出典メモ | uspto-grants-1991_05 |