Propylene Oxide → 3-Amino-2-(4-chlorophenyl)-1-hydroxy-propyl(methyl)phosphinic acid

HRID 2050739ノート

反応式

HRID 2050739 の反応式
C(OC([NH:8][CH2:9][CH:10]([C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=1)[CH:11]([P:13]([CH3:18])(=[O:17])[O:14]CC)[OH:12])=O)(C)(C)C.C1OC1C>Cl.CO>[NH2:8][CH2:9][CH:10]([C:19]1[CH:20]=[CH:21][C:22]([Cl:25])=[CH:23][CH:24]=1)[CH:11]([P:13]([CH3:18])(=[O:14])[OH:17])[OH:12]

参加物

5

反応物 2

HCID 6378Propylene OxideHCID 19090866HCID 19090866、化合物

生成物 1

HCID 99432103-Amino-2-(4-chlorophenyl)-1-hydroxy-propyl(methyl)phosphinic acid

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒

実験手順

A solution of 0.64 g of ethyl 3-(N-tert.-butyloxycarbonylamino)-2-(4-chlorophenyl)-1-hydroxy-propyl(methyl)pho sphinate in 12 ml of concentrated aqueous hydrochloric acid is heated to reflux for 5 hours. The mixture is then cooled and evaporated to dryness in vacuo. The residue is repeatedly co-evaporated with methanol until the hydrochloride salt is obtained as a foam. This is dissolved in 50 ml of methanol and treated with 25 ml of propylene oxide after 40 minutes stirring at room temperature a solid precipitates, and the suspension stirred for a further 11/2hours. The solid is collected by filtration washed with propylene oxide and ether and dried the solid is redissolved in methanol at elevated temperature and filtered. Concentration in vacuo and dilution with ether affords a solid which is collected and dried to give 3-amino-2-(4-chlorophenyl)-1-hydroxy-propyl(methyl)phosphinic acid, m.p. 240-241° C.

後処理

  1. temperatureto reflux for 5 hours
  2. temperatureThe mixture is then cooled
  3. customevaporated to dryness in vacuo
  4. customis obtained as a foam
  5. customprecipitates
  6. stirringthe suspension stirred for a further 11/2hours
  7. filtrationThe solid is collected by filtration
  8. washwashed with propylene oxide and ether
  9. customdried the solid
  10. dissolutionis redissolved in methanol at elevated temperature
  11. filtrationfiltered
  12. concentrationConcentration in vacuo and dilution with ether
  13. customaffords a solid which
  14. customis collected
  15. customdried

出典と根拠

ORDレコード
ord-47f6b20d4c9e44c289fc333ce9ba9be6
出典データセット
uspto-grants-1991_05
特許番号
US05013863

反応ノート

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