関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | Ammonium Acetate | HCID 517165 | — |
| 反応物 | ethyl-2-(N-tert-butylsulfamoyl)acetate | HCID 19833529 | — |
| 生成物 | Ethyl 3-phenyl-2-(tert.butylaminosulfonyl)prop-2-enoate | HCID 57037021 | 72% |
反応手順
11.2 g (0.05 mol) of ethyl 2-(tert.butylaminosulfonyl)acetate (see J. Org. Chem. 43, p. 4535 (1978)) are dissolved in 50 ml of benzaldehyde, 2 g of ammonium acetate and 2 ml of glacial acetic acid are added, and the mixture is stirred for 2 hours at 60° C. under a water pump vacuum (20 mm). The excess aldehyde is subsequently distilled off, and the residue is digested using n-hexane and recrystallized from isopropanol. 11.2 g (72% of theory) of ethyl 3-phenyl-2-(tert.butylaminosulfonyl)prop-2-enoate of melting point 111°-113° C. are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05015284 |
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| 出典データセット | uspto-grants-1991_05 |
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| ORD ID | ord-50e92ea2e822489f80998c8691832cdf |
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| 出典メモ | uspto-grants-1991_05 |
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