Methylamine → 8-Hydroxy-5-methyl-9-methylimino-1,2,3,4,4a,9a-hexahydrofluorene
反応式
[OH:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:16])=[C:6]2[C:14]=1[C:13](=O)[CH:12]1[CH:7]2[CH2:8][CH2:9][CH2:10][CH2:11]1.[CH3:17][NH2:18]>CO>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:16])=[C:6]2[C:14]=1[C:13](=[N:18][CH3:17])[CH:12]1[CH:7]2[CH2:8][CH2:9][CH2:10][CH2:11]1参加物
4
実験手順
To a methanol solution containing 2 g of 8-hydroxy-5-methyl-1,2,3,4,4a,9a-hexahydro-9-fluorenone in 20 ml of methanol was added 7.18 ml of methanol solution of 40% methylamine and the mixture was refluxed under heating for 5 hours. After left to stand for cooling, the solvent was removed by concentration and the residue was recrystallized from ethanol to obtain 0.35 g of 8-hydroxy-5-methyl-9-methylimino-1,2,3,4,4a,9a-hexahydrofluorene.
後処理
- temperaturethe mixture was refluxed
- temperatureunder heating for 5 hours
- waitAfter left
- temperaturefor cooling
- customthe solvent was removed by concentration
- customthe residue was recrystallized from ethanol
出典と根拠
- ORDレコード
- ord-e9e59e429944451183c34659b6913d02
- 出典データセット
- uspto-grants-1991_05
- 特許番号
- US05017724
反応ノート
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