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Methanol → N-(4-anilinophenyl)-N-(1,3-dimethyl-butyl)-thiocarbamate-O-methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Thiophosgene | HCID 10040 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1,4-Benzenediamine, N-(1,3-dimethylbutyl)-N'-phenyl- | HCID 13101 | — |
| 反応物 | Pyrrolidine | HCID 31268 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | N-(4-anilinophenyl)-N-(1,3-dimethyl-butyl)-thiocarbamate-O-methyl ester | HCID 19832480 | — |
反応手順
N-phenyl-N'-(1,3-dimethylbutyl)-p-phenylenediamine (26.8g, 0.10 mol) in 100 mL chloroform and 30g (0.22 mol) of K2CO3 as a saturated aqueous solution are placed in a 250 mL, 3-neck round bottom flask. Thiophosgene (11.5g: 0.10 mol) in 20 mL chloroform is added at such a rate sufficient to reach and maintain reflux conditions. Stirring is continued until the mixture returns to room temperature. Methanol (6.4g, 0.2 mol) is then added and the mixture refluxed for 4 hours. The organic layer is separated, dried with MgSO4 and the solvent removed on a rotary evaporator to give the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05019611 |
| 出典データセット | uspto-grants-1991_05 |
| ORD ID | ord-0d6a7e843f8543d29cec7e28e8e1f0d9 |
| 出典メモ | uspto-grants-1991_05 |