化工社化工社 化学情報印刷レポート · 研究参考用
1-Diethoxyphosphorylpropan-2-one → Phosphonic acid, (1-acetyl-9-(2-chloro-4-methoxyphenoxy)nonyl)-, diethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Diethoxyphosphorylpropan-2-one | HCID 14028 | — |
| 反応物 | Lithium hydride | HCID 62714 | — |
| 反応物 | 8-(2-Chloro-4-methoxyphenoxy)octyl iodide | HCID 23347300 | — |
| 生成物 | Phosphonic acid, (1-acetyl-9-(2-chloro-4-methoxyphenoxy)nonyl)-, diethyl ester | HCID 5271399 | 25% |
反応手順
[II; Ar is 2-Cl-4-CH3OC6H3, Y is O(CH2)8, R is C2H5, R' is CH3CO] was prepared from 0.38 g of lithium hydride, 9.5 g of diethyl acetonylphosphonate and 19.4 g of 8-(2-chloro-4-methoxyphenoxy)octyl iodide according to the procedure of Example 12(b). The product was chromatographed on Florisil to give 5.67 g of diethyl [1-acetyl-9-(2-chloro-4-methoxyphenoxy)nonyl]phosphonate as a light yellow oil; MIC vs. herpes simplex type 2=12 mcg/ml. The NMR spectrum was consistent with the assigned structure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04182759 |
| 出典データセット | uspto-grants-1980_01 |
| ORD ID | ord-93c1cd86511248c5b36e264148d67727 |
| 出典メモ | uspto-grants-1980_01 |