Furfural → 1-{[(Furan-2-yl)methylidene]amino}piperazine-2,3-dione

HRID 2051762

反応式

HRID 2051762 の反応式
[CH:1](=O)[C:2]1[O:6][CH:5]=[CH:4][CH:3]=1.[NH2:8][N:9]1[CH2:14][CH2:13][NH:12][C:11](=[O:15])[C:10]1=[O:16]>C(O)(=O)C>[CH:1](=[N:8][N:9]1[CH2:14][CH2:13][NH:12][C:11](=[O:15])[C:10]1=[O:16])[C:2]1[O:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 7362FurfuralHCID 221847681-Aminopiperazine-2,3-dione

生成物 1

HCID 539190641-{[(Furan-2-yl)methylidene]amino}piperazine-2,3-dione収率 96.6%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

2.3 pts. by wt. of furfural, 2.6 pts. by wt. of 1-amino-2,3-dioxo-piperazine and 10 pts. by vol. of glacial acetic acid are warmed to 90° for 30 minutes and thereafter left for 3 hrs. at RT, whereupon crystallisation occurs. The precipitate is filtered off, washed first with 5 pts. by vol. of glacial acetic acid and then twice with 10 pts. by vol. of ethyl acetate each time and dried over potassium hydroxide. 4.0 pts. by wt. (96.6%) of 1-furfurylideneamino-2,3-dioxo-piperazine of melting point 193°-7° are obtained.

後処理

  1. customat RT, whereupon crystallisation
  2. filtrationThe precipitate is filtered off
  3. washwashed first with 5 pts
  4. dry with materialby vol. of ethyl acetate each time and dried over potassium hydroxide

出典と根拠

ORDレコード
ord-b1e3f3bc06e1478dba0abdadf264a719
出典データセット
uspto-grants-1980_01
特許番号
US04182762

関連ノート

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