Potassium Cyanide → 5-(2-Cyano-5-oxocyclopentyl)pentyl acetate

HRID 2051784ノート

反応式

HRID 2051784 の反応式
[C-:1]#[N:2].[K+].[C:4]([O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[C:14](=[O:18])[CH2:15][CH2:16][CH:17]=1)(=[O:6])[CH3:5]>CO.C(O)(=O)C>[C:4]([O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH:13]1[C:14](=[O:18])[CH2:15][CH2:16][CH:17]1[C:1]#[N:2])(=[O:6])[CH3:5]

参加物

5

反応物 2

HCID 9032Potassium CyanideHCID 132897885-(5-Oxocyclopent-1-en-1-yl)pentyl acetate

生成物 1

HCID 203783085-(2-Cyano-5-oxocyclopentyl)pentyl acetate

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 887Methanol溶媒

実験手順

98 g [1.5 mols] of potassium cyanide were suspended in 600 ml of methanol, and 105 g [0.5 mol] of 2-(5-acetoxypentyl)- cyclopent-2-ene-1-one, dissolved in 45 ml of acetic acid, were added dropwise within 2.5 hours. After 20 hours, agitation at room temperature, the suspension was dropped into ice-water with agitation, extracted thrice with diethyl ether, the ether phases were united, washed with water, dried over sodium sulfate and concentrated. The oily residue was stirred for 5 hours at room temperature in 200 ml of pyridine and 30 ml of acetic anhydride, the solvent was then distilled off under reduced pressure and the residue was distilled in a bulb tube. 102 g having a boiling point of 180° C. at 0.4 mm Hg were obtained; IR spectrum: 2220 cm-1.

後処理

  1. additionwere added dropwise within 2.5 hours
  2. extractionextracted thrice with diethyl ether
  3. washwashed with water
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated
  6. distillation30 ml of acetic anhydride, the solvent was then distilled off under reduced pressure
  7. distillationthe residue was distilled in a bulb tube
  8. customwere obtained

出典と根拠

ORDレコード
ord-3fcd70aa684844a08e73ab3c27e6bbdf
出典データセット
uspto-grants-1980_01
特許番号
US04182773

反応ノート

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