HCID 22809705、化合物 → HCID 22809701、化合物

HRID 2051820ノート

反応式

HRID 2051820 の反応式
[Cl:1][CH2:2][CH2:3][NH:4][C:5]([N:7]([CH:19]([CH2:21][CH3:22])[CH3:20])[CH:8]1[O:16][C@H:15]([CH2:17][OH:18])[C@H:13]([OH:14])[C@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6].[N:23]([O-])=[O:24].[Na+]>C(O)=O>[Cl:1][CH2:2][CH2:3][N:4]([N:23]=[O:24])[C:5]([N:7]([CH:19]([CH2:21][CH3:22])[CH3:20])[CH:8]1[O:16][C@H:15]([CH2:17][OH:18])[C@H:13]([OH:14])[C@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6]

参加物

4

反応物 2

HCID 22809705HCID 22809705、化合物HCID 23668193Sodium Nitrite

生成物 1

HCID 22809701HCID 22809701、化合物収率 22.4%

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

7.0 g of 1-(2-chloroethyl)-3-sec.butyl-3-D-galactopyranosylurea are dissolved in 20 ml of formic acid, and 5.0 g of sodium nitrite are added gradually thereto at 0° to 5° C. for one hour under stirring. The mixture is further stirred at the same temperature for one hour. After the reaction, the mixture is treated in the same manner as described in Example 5-(2). 1.7 g of 1-(2-chloroethyl)-1-nitroso-3-sec.butyl-3-D-galactopyranosylurea are thereby obtained as pale yellow caramel.

後処理

  1. stirringThe mixture is further stirred at the same temperature for one hour
  2. customAfter the reaction
  3. additionthe mixture is treated in the same manner

出典と根拠

ORDレコード
ord-b0fadd03a7964a278abafdc1f4fa3136
出典データセット
uspto-grants-1980_01
特許番号
US04182757

反応ノート

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