Potassium Hydroxide → 4-{[2-(Thiophen-2-yl)ethyl]amino}benzoic acid

HRID 2051895ノート

反応式

HRID 2051895 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][NH:8][C:9]1[CH:19]=[CH:18][C:12]([C:13]([O:15]CC)=[O:14])=[CH:11][CH:10]=1.[OH-].[K+]>C(O)C>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][NH:8][C:9]1[CH:19]=[CH:18][C:12]([C:13]([OH:15])=[O:14])=[CH:11][CH:10]=1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 13079686Ethyl 4-{[2-(thiophen-2-yl)ethyl]amino}benzoate

生成物 1

HCID 130796854-{[2-(Thiophen-2-yl)ethyl]amino}benzoic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 29.7 g of ethyl p-[2-(2-thienyl)ethylamino]benzoate and 29 g of potassium hydroxide in 200 ml of 95% ethanol is refluxed for 3 hours. The mixture is worked up as described in Example 4 to give the product, mp 161°-163° C.

後処理

  1. temperatureis refluxed for 3 hours
  2. customto give the product, mp 161°-163° C.

出典と根拠

ORDレコード
ord-ba5a26e36bb14055959012221e18e860
出典データセット
uspto-grants-1980_01
特許番号
US04182776

反応ノート

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