Hydrochloric Acid → p-{[2-(2-Naphthyloxy)ethyl]amino}benzoic acid

HRID 2051920ノート

反応式

HRID 2051920 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH2:12][CH2:13][NH:14][C:15]1[CH:25]=[CH:24][C:18]([C:19]([O:21]CC)=[O:20])=[CH:17][CH:16]=1.[OH-].[K+].Cl>C(O)C.O.O>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH2:12][CH2:13][NH:14][C:15]1[CH:25]=[CH:24][C:18]([C:19]([OH:21])=[O:20])=[CH:17][CH:16]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 23468273Ethyl p-{[2-(2-naphthyloxy)ethyl]amino}benzoate

生成物 1

HCID 23468295p-{[2-(2-Naphthyloxy)ethyl]amino}benzoic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 19096565Water ethanol溶媒

実験手順

A mixture of 3.0 g of ethyl p-{[2-(2-naphthyloxy)-ethyl]amino}benzoate, and 3.0 g of potassium hydroxide in 200 ml of ethanol-water (95:5) is refluxed for 3 hours. The mixture is diluted with 100 ml of water and brought to pH 6.0 with concentrated hydrochloric acid. The mixture is filtered and the solid washed with 50 ml of water and 20 ml of cold ethanol-water (4:1) to give the product, mp 208°-211° C.

後処理

  1. temperatureis refluxed for 3 hours
  2. filtrationThe mixture is filtered
  3. washthe solid washed with 50 ml of water and 20 ml of cold ethanol-water (4:1)
  4. customto give the product, mp 208°-211° C.

出典と根拠

ORDレコード
ord-f6ebdbaed33e415fbc59f1491b6d7e68
出典データセット
uspto-grants-1980_01
特許番号
US04182776

反応ノート

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