Triethylamine → HCID 10967402、化合物
反応式
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][CH2:8][CH2:9][OH:10])=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH3:20][S:21](Cl)(=[O:23])=[O:22]>ClCCl>[CH3:20][S:21]([O:10][CH2:9][CH2:8][CH2:7][O:6][C:5]1[CH:11]=[CH:12][C:2]([Cl:1])=[CH:3][CH:4]=1)(=[O:23])=[O:22]参加物
5
実験手順
To a solution of 9.7 g of 3-(4-chlorophenoxy)-1-propanol and 10.5 g of triethylamine in 250 ml of dichloromethane chilled to -5° C. is added dropwise 6.7 g of methanesulfonyl chloride. After chilling and stirring for 1 hour, the mixture is washed with chilled 100 ml portions of water, 10% hydrochloric acid, saturated sodium bicarbonate, and saturated sodium chloride. The organic layer is dried (magnesium sulfate) and the solvent removed under vacuum to give the product as an oil which crystallizes on standing.
後処理
- temperatureAfter chilling
- washthe mixture is washed
- temperaturewith chilled 100 ml portions of water, 10% hydrochloric acid, saturated sodium bicarbonate, and saturated sodium chloride
- dry with materialThe organic layer is dried (magnesium sulfate)
- customthe solvent removed under vacuum
出典と根拠
- ORDレコード
- ord-88137924cc7f4ab6a2837bf10b6e8b8e
- 出典データセット
- uspto-grants-1980_01
- 特許番号
- US04182776
反応ノート
読み込み中…