1-Amino-2-methylanthraquinone → 1-Amino-4-bromo-2-methylanthraquinone

HRID 2052121

反応式

HRID 2052121 の反応式
[NH2:1][C:2]1[C:15]2[C:14](=[O:16])[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7](=[O:17])[C:6]=2[CH:5]=[CH:4][C:3]=1[CH3:18].[Br:19]Br>CC(O)=O>[NH2:1][C:2]1[C:15]2[C:14](=[O:16])[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7](=[O:17])[C:6]=2[C:5]([Br:19])=[CH:4][C:3]=1[CH3:18]

参加物

4

反応物 2

HCID 67021-Amino-2-methylanthraquinoneHCID 24408Bromine

生成物 1

HCID 664801-Amino-4-bromo-2-methylanthraquinone収率 90%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
40 °C

実験手順

1-amino-2-methylanthraquinone (300 g) is slurried with 1500 ml of HOAc in a 5-liter flask. The temperature is raised to 40° C. Neat bromine (405 g) is added over 21/2 hours with stirring at 40°-50° C. The mixture is stirred for 20 additional minutes and filtered. The solids so recovered are washed with HOAc and water and sucked dry with an aspirator and transferred to a reaction flask along with 150 g of NaHSO3 and 1.5 liters of water. The mixture is gradually heated to 90° C. (over two hours) with stirring to give 1-amino-2-methyl-4-bromoanthraquinone as a solid which is recovered from the reaction mixture by filtration in 90% yield, rinsed with water and dried overnight at 155° C. and 1 mm Hg absolute vacuum.

後処理

  1. stirringThe mixture is stirred for 20 additional minutes
  2. filtrationfiltered
  3. customThe solids so recovered
  4. washare washed with HOAc and water
  5. customsucked dry with an aspirator
  6. customtransferred to a reaction flask along with 150 g of NaHSO3 and 1.5 liters of water
  7. temperatureThe mixture is gradually heated to 90° C. (over two hours)
  8. stirringwith stirring

出典と根拠

ORDレコード
ord-4439942990c942e1a4711bf0bd24706c
出典データセット
uspto-grants-1980_01
特許番号
US04182885

関連ノート

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