3-Isoxazolamine, 5-(1,1-dimethylethyl)- → N'-(5-tert-Butyl-1,2-oxazol-3-yl)-N-ethyl-N-methylurea

反応式

[NH2:1][C:2]1[CH:6]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[O:4][N:3]=1.[CH2:11]([N:13]([CH3:17])[C:14](Cl)=[O:15])[CH3:12]>>[CH2:11]([N:13]([CH3:17])[C:14]([NH:1][C:2]1[CH:6]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[O:4][N:3]=1)=[O:15])[CH3:12]

参加物

反応物 2

HCID 1714733-Isoxazolamine, 5-(1,1-dimethylethyl)-

HCID 11240471N-Ethyl-N-methylcarbamoyl chloride

生成物 1

HCID 20377186N'-(5-tert-Butyl-1,2-oxazol-3-yl)-N-ethyl-N-methylurea収率 96.1%

実験手順

Using 3-amino-5-t-butylisoxazole and N-ethyl-N-methylcarbamoyl chloride, the reaction is carried out as in Example 1, whereby 1-ethyl-1-methyl-3-(5-t-butyl-3-isoxazolyl)urea is obtained. Yield is 96.1%. Melting point is 88.5° to 89.5° C.

出典と根拠

ORDレコード: ord-59e1e22ca06e4113b88daf0baf0e3cfc
出典データセット: uspto-grants-1980_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04183856

反応ノート

読み込み中…