3-Isoxazolamine, 5-(1,1-dimethylethyl)- → N'-(5-tert-Butyl-1,2-oxazol-3-yl)-N-methoxy-N-methylurea

反応式

[NH2:1][C:2]1[CH:6]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[O:4][N:3]=1.[CH3:11][O:12][N:13]([CH3:17])[C:14](Cl)=[O:15]>>[CH3:11][O:12][N:13]([CH3:17])[C:14]([NH:1][C:2]1[CH:6]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[O:4][N:3]=1)=[O:15]

参加物

反応物 2

HCID 1714733-Isoxazolamine, 5-(1,1-dimethylethyl)-

HCID 2734926N-methoxy-N-methylcarbamoyl chloride

生成物 1

HCID 14091973N'-(5-tert-Butyl-1,2-oxazol-3-yl)-N-methoxy-N-methylurea収率 94.7%

実験手順

Using 3-amino-5-t-butylisoxazole and N-methoxy-N-methylcarbamoyl chloride, the reaction is run as in Example 1, whereby 1-methoxy-1-methyl-3-(5-t-butyl-3-isoxazolyl)urea is obtained. Yield is 94.7%. Melting point is 106.0° to 107.0° C.

出典と根拠

ORDレコード: ord-fb6c0be2b25b4be191d228b756633d58
出典データセット: uspto-grants-1980_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04183856

反応ノート

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