Hydrochloric Acid → 3-(3-Methoxyphenyl)-2-oxopropanoic acid

HRID 2052458

反応式

HRID 2052458 の反応式
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[CH:3]=1.C(N[CH2:15][C:16]([OH:18])=[O:17])(=O)C.C([O-])(=[O:21])C.[Na+].Cl>C(OC(=O)C)(=O)C.O>[CH3:9][O:8][C:4]1[CH:3]=[C:2]([CH2:1][C:15](=[O:21])[C:16]([OH:18])=[O:17])[CH:7]=[CH:6][CH:5]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 10972AcetylglycineHCID 115693-MethoxybenzaldehydeHCID 517045Sodium Acetate

生成物 1

HCID 2900913-(3-Methoxyphenyl)-2-oxopropanoic acid収率 34.1%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 7918Acetic Anhydride溶媒

実験手順

m-Anisaldehyde (25.9 g), N-acetylglycine (15.2 g) and sodium acetate (7.8 g) were heated together under reflux in acetic anhydride (50 ml) for 3/4 hour. The mixture was allowed to cool, water (150 ml) was added and the mixture was filtered to give the crude azlactone (27.7 g) m.p. 145-150°. Hydrolysis with boiling 1N hydrochloric acid (450 ml) followed by cooling and ether extraction afforded 3-methoxyphenylpyruvic acid as a pale yellow oily solid (6.3 g).

後処理

  1. temperatureto cool
  2. filtrationthe mixture was filtered
  3. customto give the crude azlactone (27.7 g) m.p. 145-150°
  4. customHydrolysis
  5. temperatureby cooling
  6. extractionether extraction

出典と根拠

ORDレコード
ord-59bcdeed26b04425bd138f9ea0027608
出典データセット
uspto-grants-1980_01
特許番号
US04185103

関連ノート

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