Maleic Acid → HCID 70585028、化合物

HRID 2052472ノート

反応式

HRID 2052472 の反応式
[NH2:1][C:2]1[C:17]([Br:18])=[CH:16][C:15]([Br:19])=[CH:14][C:3]=1[CH2:4][NH:5][C@H:6]([C:11]([OH:13])=[O:12])[CH2:7][CH2:8][S:9][CH3:10].[C:20]([OH:27])(=[O:26])/[CH:21]=[CH:22]\[C:23]([OH:25])=[O:24]>C(O)(=O)C>[C:20]([OH:27])(=[O:26])/[CH:21]=[CH:22]\[C:23]([OH:25])=[O:24].[NH2:1][C:2]1[C:17]([Br:18])=[CH:16][C:15]([Br:19])=[CH:14][C:3]=1[CH2:4][NH:5][C@H:6]([C:11]([OH:13])=[O:12])[CH2:7][CH2:8][S:9][CH3:10]

参加物

4

反応物 2

HCID 444266Maleic AcidHCID 13340374N-[(2-Amino-3,5-dibromophenyl)methyl]-L-methionine

生成物 1

HCID 70585028HCID 70585028、化合物収率 84%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
20 °C

実験手順

100 gm of N-(2-amino-3.5-dibromo-benzyl)-methionine were dissolved in 500 ml of hot acetic acid, and then, while stirring and heating the solution at the boiling point, 28 gm of maleic acid were added. After it had dissolved, the solution was cooled to 20° C. while stirring was continued, and the precipitated product was centrifuged off, washed with a little acetic acid and then with isopropylic acid, and after drying at 60° C. in a ventilated drying chamber, 107 gm of the desired product were obtained in the form of white crystals, which melted at 205° C.

後処理

  1. additionwere added
  2. dissolutionAfter it had dissolved
  3. stirringwhile stirring
  4. washwashed with a little acetic acid
  5. customwith isopropylic acid, and after drying at 60° C. in
  6. customa ventilated drying chamber

出典と根拠

ORDレコード
ord-01ef2efad7d14fa9b8b9cfdf5926dfaf
出典データセット
uspto-grants-1980_01
特許番号
US04185114

反応ノート

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