Hydrochloric Acid → 4-(Benzylamino)benzoic acid
反応式
[CH2:1]([NH:8][C:9]1[CH:19]=[CH:18][C:12]([C:13]([O:15]CC)=[O:14])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)C.O.[OH-].[K+].Cl>O>[CH2:1]([NH:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]([OH:15])=[O:14])=[CH:18][CH:19]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
6
実験手順
A mixture of 6.0 g. of ethyl p-benzylaminobenzoate (prepared as described in Example 9), 100 ml. of ethanol-water (9:1) and 6.0 g. of potassium hydroxide are refluxed for 3.5 hours. The mixture is acidified with concentrated hydrochloric acid, diluted with water, chilled, filtered and the solid washed with water to give pale cream crystals, m.p. 165°-168° C. Recrystallization from ethanol gives tan crystals, m.p. 167°-169° C.
後処理
- additionA mixture of 6.0 g
- temperaturechilled
- filtrationfiltered
- washthe solid washed with water
- customto give pale cream crystals, m.p. 165°-168° C
- customRecrystallization from ethanol
- customgives tan crystals, m.p. 167°-169° C.
出典と根拠
- ORDレコード
- ord-a142c9540a59429a84ed47ac7389c295
- 出典データセット
- uspto-grants-1980_01
- 特許番号
- US04185115
反応ノート
読み込み中…