Hydrochloric Acid → 4-({[4-(Benzyloxy)phenyl]methyl}amino)benzoic acid

HRID 2052485ノート

反応式

HRID 2052485 の反応式
[CH2:1]([O:8][C:9]1[CH:27]=[CH:26][C:12]([CH2:13][NH:14][C:15]2[CH:25]=[CH:24][C:18]([C:19]([O:21]CC)=[O:20])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+].Cl>C(O)C.O>[CH2:1]([O:8][C:9]1[CH:27]=[CH:26][C:12]([CH2:13][NH:14][C:15]2[CH:16]=[CH:17][C:18]([C:19]([OH:21])=[O:20])=[CH:24][CH:25]=2)=[CH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 13079673Ethyl 4-({[4-(benzyloxy)phenyl]methyl}amino)benzoate

生成物 1

HCID 130796724-({[4-(Benzyloxy)phenyl]methyl}amino)benzoic acid

試薬・触媒・溶媒 1

HCID 19096565Water ethanol溶媒

実験手順

A mixture of 10 g. of ethyl p-[p-(benzyloxy)benzylamino]benzoate (prepared as described in Example 11) 10 g. of potassium hydroxide and 200 ml. of ethanol-water (9:1) are refluxed for 4.5 hours. While hot, the mixture is acidified with concentrated hydrochloric acid. Dilution with water and filtration gives tan crystals which are recrystallized from glacial acetic acid to give off-white crystals, m.p. 206°-208° C.

後処理

  1. additionA mixture of 10 g
  2. filtrationDilution with water and filtration
  3. customgives tan crystals which
  4. customare recrystallized from glacial acetic acid
  5. customto give off-white crystals, m.p. 206°-208° C.

出典と根拠

ORDレコード
ord-c8ad0d790e8f408a9a811561f269b2d0
出典データセット
uspto-grants-1980_01
特許番号
US04185115

反応ノート

読み込み中…