Hydrochloric Acid → 4-({2-[4-(Benzyloxy)phenyl]ethyl}amino)benzoic acid

HRID 2052488ノート

反応式

HRID 2052488 の反応式
[CH2:1]([O:8][C:9]1[CH:28]=[CH:27][C:12]([CH2:13][CH2:14][NH:15][C:16]2[CH:26]=[CH:25][C:19]([C:20]([O:22]CC)=[O:21])=[CH:18][CH:17]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+].C(O)C.O.Cl>O>[CH2:1]([O:8][C:9]1[CH:28]=[CH:27][C:12]([CH2:13][CH2:14][NH:15][C:16]2[CH:17]=[CH:18][C:19]([C:20]([OH:22])=[O:21])=[CH:25][CH:26]=2)=[CH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 13079675Ethyl 4-({2-[4-(benzyloxy)phenyl]ethyl}amino)benzoateHCID 19096565Water ethanol

生成物 1

HCID 130796744-({2-[4-(Benzyloxy)phenyl]ethyl}amino)benzoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 6.0 g. of ethyl p-[(p-benzyloxyphenethyl)amino]benzoate (prepared as described in Example 18) 6.0 g. of potassium hydroxide and 100 ml. of ethanol-water (9:1) is refluxed for 3.5 hours. The mixture is acidified while hot with concentrated hydrochloric acid, diluted with water, filtered and the solid washed with water to give tan crystals, m.p. 180°-185° C. Recrystallization from glacial acetic acid gives tan crystals, m.p. 187°-189° C.

後処理

  1. additionA mixture of 6.0 g
  2. filtrationfiltered
  3. washthe solid washed with water
  4. customto give tan crystals, m.p. 180°-185° C
  5. customRecrystallization from glacial acetic acid
  6. customgives tan crystals, m.p. 187°-189° C.

出典と根拠

ORDレコード
ord-6721018539f74b538bc6243b5a66f9d0
出典データセット
uspto-grants-1980_01
特許番号
US04185115

反応ノート

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