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Benzocaine → Ethyl 4-{[3-(4-chlorophenyl)propyl]amino}benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzocaine | HCID 2337 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Hexamethylphosphoramide | HCID 12679 | — |
| 反応物 | 3-(4-Chlorophenyl)propyl methanesulfonate | HCID 13079705 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Ethyl 4-{[3-(4-chlorophenyl)propyl]amino}benzoate | HCID 13079692 | — |
反応手順
A solution of 49.5 g. of ethyl 4-aminobenzoate, 34.9 g. of 3-(p-chlorophenyl)propanol O-mesylate in 100 ml. of hexamethylphosphoramide is heated at 125°-130° C. for 16 hours. The solution is diluted with 50 ml. of tetrahydrofuran and with 150 ml. of water. Chilling and filtering gives crystals which are washed with water and recrystallized from ethanol to give 28.3 g. of light yellow crystals. Recrystallizations give the product as crystals, m.p. 122°-124° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04185115 |
| 出典データセット | uspto-grants-1980_01 |
| ORD ID | ord-393350e9c5234997b8aa07446456191c |
| 出典メモ | uspto-grants-1980_01 |