2-phenyl-1H-imidazole-4-carboxylic acid → {3-[(2-phenyl-1H-imidazole-5-carbonyl)-amino]-phenyl}acetic acid ethyl ester

反応式

[C:1]1([C:7]2[NH:8][C:9]([C:12]([OH:14])=O)=[CH:10][N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:15]([O:17][C:18](=[O:27])[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([NH2:26])[CH:21]=1)[CH3:16]>>[CH2:15]([O:17][C:18](=[O:27])[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([NH:26][C:12]([C:9]2[NH:8][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[N:11][CH:10]=2)=[O:14])[CH:21]=1)[CH3:16]

参加物

反応物 2

HCID 27381392-phenyl-1H-imidazole-4-carboxylic acid

HCID 13042040Ethyl 2-(3-aminophenyl)acetate

生成物 1

HCID 59654856{3-[(2-phenyl-1H-imidazole-5-carbonyl)-amino]-phenyl}acetic acid ethyl ester

実験手順

2-Phenyl-1H-imidazole-5-carboxylic acid (105 mg, 0.56 mmol) was coupled with ethyl ester (6) (100 mg, 0.56 mmol) following Method C to give the title compound.

出典と根拠

ORDレコード: ord-c708944a9bef4b42bdf3468b768e4830
出典データセット: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07326732B2

反応ノート

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