5-(3-Chlorophenyl)furan-2-carboxylic acid → 5-{[5-(3-Chloro-phenyl)-furan-2-carbonyl]-amino}-1H-indole-2-carboxylic acid ethyl ester

HRID 2053182

反応式

HRID 2053182 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][C:11]([C:13]([OH:15])=O)=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:16]([O:18][C:19]([C:21]1[NH:22][C:23]2[C:28]([CH:29]=1)=[CH:27][C:26]([NH2:30])=[CH:25][CH:24]=2)=[O:20])[CH3:17]>>[CH2:16]([O:18][C:19]([C:21]1[NH:22][C:23]2[C:28]([CH:29]=1)=[CH:27][C:26]([NH:30][C:13]([C:11]1[O:12][C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)=[CH:9][CH:10]=1)=[O:15])=[CH:25][CH:24]=2)=[O:20])[CH3:17]

参加物

3

反応物 2

HCID 7362565-(3-Chlorophenyl)furan-2-carboxylic acidHCID 10726872Ethyl 5-amino-1H-indole-2-carboxylate

生成物 1

HCID 596546335-{[5-(3-Chloro-phenyl)-furan-2-carbonyl]-amino}-1H-indole-2-carboxylic acid ethyl ester

実験手順

5-(3-Chloro-phenyl)-furan-2-carboxylic acid (65) (54 mg, 0.24 mmol) was coupled to ethyl ester (58) (50 mg, 0.24 mmol) using Method C. The crude residue was purified by column chromatography eluting with 20% EtOAc in heptane to give the title compound.

後処理

  1. customThe crude residue was purified by column chromatography
  2. washeluting with 20% EtOAc in heptane

出典と根拠

ORDレコード
ord-a4a0c2e2cc1b4c928b3665909ce4d6e5
出典データセット
uspto-grants-2008_02
特許番号
US07326732B2

関連ノート

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