Ethyl Acetate → 3-(Cyanomethyl)benzonitrile
反応式
Br[CH2:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[C:6]#[N:7].[C-:11]#[N:12].[K+].CCOC(C)=O>CN(C=O)C.O>[C:11]([CH2:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[C:6]#[N:7])#[N:12]参加物
6
反応条件
- 温度
- 85 °C
実験手順
3-Bromomethyl-benzonitrile (150 mg, 0.76 mmol) was dissolved in DMF (2 ml). KCN (55 mg, 0.84 mmol) was dissolved in the minimum amount of water and was added to the reaction. The resulting solution was stirred at 85° C. overnight. The reaction mixture was allowed to cool to room temperature, EtOAc (5 ml) was added, and the solution was washed with saturated NaHCO3 (4×10 ml). The organic layer was dried (MgSO4), filtered and the solvent removed in vacuo to give the title compound.
後処理
- additionwas added to the reaction
- temperatureto cool to room temperature
- washthe solution was washed with saturated NaHCO3 (4×10 ml)
- dry with materialThe organic layer was dried (MgSO4)
- filtrationfiltered
- customthe solvent removed in vacuo
出典と根拠
- ORDレコード
- ord-5de09d38c37a4ae49789a59702aefea2
- 出典データセット
- uspto-grants-2008_02
- 特許番号
- US07326732B2
反応ノート
読み込み中…