HCID 69214722、化合物 → HCID 69216568、化合物
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5](Br)=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([CH2:17][CH3:18])=[CH:13][CH:12]=1)=[O:10].[Cu](C#N)[C:20]#[N:21]>CN(C=O)C>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:20]#[N:21])=[CH:4][C:3]=1[C:9](=[O:10])[C:11]1[CH:16]=[CH:15][C:14]([CH2:17][CH3:18])=[CH:13][CH:12]=1参加物
4
反応条件
- 温度
- 180 °C
実験手順
A flask charged with (2-amino-5-bromo-phenyl)-(4-ethyl-phenyl)-methanone (0.10 g, 0.32 mmol), copper cyanide (0.0347 g, 0.41 mmol), and 1 mL of DMF was heated at 180° C. for 1 hour in a microwave reactor. The title compound was eluted from a 5 g SPE with 100% DCM to give 0.07 g (81%) of a white solid. 1H NMR (400 MHz, CDCl3) δ 7.84 (d, 1H), 7.58 (d, 2H), 7.50 (dd, 1H), 7.36 (d, 2H), 6.78 (d, 1H), 6.60 (br s, 2H), 2.78 (q, 2H), 1.30 (t, 3H). This was prepared according to example 41. 1H NMR (400 MHz, CD3OD) δ 8.60 (s, 1H), 7.90 (dd, 1H), 7.50 (m, 4H), 7.22 (d, 2H), 6.48 (s, 1H), 2.82 (q, 2H), 1.36 (t, 3H). Mass spectrum (ESI, m/z) calcd. for C21H16N4O 340.1, found 341.1 (M+H).