(2S,3S)-N-butyl-3-azido-2-hydroxyheptanamide → (2S,3S)-N-butyl-3-amino-2-hydroxyheptanamide

HRID 2053477ノート

反応式

HRID 2053477 の反応式
[CH2:1]([NH:5][C:6](=[O:17])[C@@H:7]([OH:16])[C@@H:8]([N:13]=[N+]=[N-])[CH2:9][CH2:10][CH2:11][CH3:12])[CH2:2][CH2:3][CH3:4]>[C].[Pd].CO>[CH2:1]([NH:5][C:6](=[O:17])[C@@H:7]([OH:16])[C@@H:8]([NH2:13])[CH2:9][CH2:10][CH2:11][CH3:12])[CH2:2][CH2:3][CH3:4]

参加物

4

反応物 1

HCID 59655565(2S,3S)-N-butyl-3-azido-2-hydroxyheptanamide

生成物 1

HCID 59655570(2S,3S)-N-butyl-3-amino-2-hydroxyheptanamide収率 94%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

To 30 ml of a methanol solution containing 304 mg (1.25 mmol) of (2S,3S)-N-butyl-3-azido-2-hydroxyheptanamide was added 30 mg of 5% palladium carbon, and the resulting mixture was stirred under hydrogen atmosphere for 18 hours. Insoluble materials were filtered off, and the filtrate was distilled under reduced pressure to obtain 254 mg (Yield: 94%) of the title compound.

後処理

  1. filtrationInsoluble materials were filtered off
  2. distillationthe filtrate was distilled under reduced pressure

出典と根拠

ORDレコード
ord-54eeba36932747d3ab2e8e016b11c279
出典データセット
uspto-grants-2008_02
特許番号
US07326799B2

反応ノート

読み込み中…