Hydrochloric Acid → (4S,5R)-N-benzyl-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-amine;hydrochloride

HRID 2053519ノート

反応式

HRID 2053519 の反応式
[ClH:1].C(OC([N:9]1[C@H:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C@H:12]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:11]=[C:10]1[NH:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=O)(C)(C)C>CCOC(C)=O>[ClH:1].[C:14]1([C@H:13]2[C@@H:12]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[NH:11][C:10]([NH:26][CH2:27][C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)=[N:9]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 68567154tert-butyl (4S,5R)-2-(benzylamino)-4,5-diphenyl-4,5-dihydroimidazole-1-carboxylate

生成物 1

HCID 68570665(4S,5R)-N-benzyl-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-amine;hydrochloride

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Hydrogen chloride is bubbled into a solution of 77 (200 mg, 0.47 mmol) in EtOAc (10 mL) for 1 min, and the solution is stirred at RT overnight. The solvent is removed by rotary evaporation, and the residue is crystallized from dichloromethane and Et2O to give 130 mg of the product 78. 1H NMR (DMSO-d6) δ 9.80-8.30 (m, 3H), 7.60-7.30 (m, 5H), 7.20-7.00 (m, 6H), 7.00-6.85 (m, 4H), 5.49 (s, 2H), 4.59 (d, 2H); MS: m/z 328 (M++1).

後処理

  1. customThe solvent is removed by rotary evaporation
  2. customthe residue is crystallized from dichloromethane and Et2O

出典と根拠

ORDレコード
ord-149f2287fcb84cf9b32d5bb2b6110a93
出典データセット
uspto-grants-2008_02
特許番号
US07326792B2

反応ノート

読み込み中…