化工社化工社 化学情報印刷レポート · 研究参考用
HRID 2053531作成日：2026年10月26日
2-(2-Fluorophenyl)ethylamine → tert-butyl (4S,5R)-2-[2-(2-fluorophenyl)ethylamino]-4,5-diphenyl-4,5-dihydroimidazole-1-carboxylate
https://huagongshe.com/reaction/2053531
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-(2-Fluorophenyl)ethylamine | HCID 643357 | — |
| 反応物 | cis-4,5-Diphenyl-2-methylthio-4,5-dihydro-imidazole-1-carboxylic Acid, Tert-Butyl Ester | HCID 86596320 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | tert-butyl (4S,5R)-2-[2-(2-fluorophenyl)ethylamino]-4,5-diphenyl-4,5-dihydroimidazole-1-carboxylate | HCID 68570675 | 43.2% |
反応手順
A mixture of intermediate 59 (0.5 g, 1.36 mmol), 2-fluorophenethylamine (0.531 mL, 4.07 mmol) and MeOH (0.1 mL) is heated at 100° C. for 3 days. The reaction mixture is cooled to RT, and is purified by chromatography on silica gel; gradient elution with heptane:EtOAc (70:30-60:40) gives 0.27 g of the product 91. 1H NMR (CDCl3) δ 7.40-6.85 (m, 13H), 6.80-6.65 (m, 2H), 5.45-5.25 (m, 2H), 3.90-3.60 (m, 2H), 1.15 (s, 9H); MS: m/z 460 (M++1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07326792B2 |
|---|
| 出典データセット | uspto-grants-2008_02 |
|---|
| ORD ID | ord-a51d4890194d4f4bb726fd1f7be3b579 |
|---|
| 出典メモ | uspto-grants-2008_02 |
|---|
