m-Xylyl chloride → 2-[(3-Methylbenzyl)thio]-cis-4,5-diphenyl-4,5-dihydro-1H-imidazole Hydrochloride

関与物質

反応手順

A mixture of intermediate 25 (200 mg, 0.786 mmol) and 3-methylbenzyl chloride (0.207 mL, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 180 mg of the product 212. 1H NMR (DMSO-d6) δ 11.21 (s, 2H), 7.50-7.20 (m, 4H), 7.20-6.90 (m, 6H), 6.90-6.65 (m, 4H), 5.73 (s, 2H), 4.75 (s, 2H), 2.32 (s, 3H); MS: m/z 359 (M++1).

情報源と証拠