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Ethyl diazoacetate → (2-Phenoxy)ethoxyacetic Acid Ethyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl diazoacetate | HCID 12192 | — |
| 反応物 | Phenoxyethanol | HCID 31236 | — |
| 触媒 | Acetic acid, rhodium salt (4:2) | HCID 423677 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Heptane | HCID 8900 | — |
| 生成物 | (2-Phenoxy)ethoxyacetic Acid Ethyl Ester | HCID 33787264 | 82.8% |
反応手順
To a solution of 2-phenoxyethan-1-ol (1.5 mL, 12.7 mmol) in dichloromethane (50 mL) is added rhodium (II) acetate dimer (10 mg) followed by ethyl diazoacetate (1.1 mL, 10.5 mmol). The reaction mixture is stirred at rt overnight. The reaction mixture is diluted with heptane, and filtered. The filtrate is evaporated, and the residue vacuum distilled to give 1.95 g of the product 440. 1H NMR (CDCl3) δ 7.40-7.25 (m, 2H), 7.10-6.90 (m, 3H), 4.30-4.15 (m, 5H), 4.15-4.05 (m, 1H), 4.05-3.90 (s, 2H), 1.28 (t, 3H)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07326792B2 |
| 出典データセット | uspto-grants-2008_02 |
| ORD ID | ord-d6f55f5ffb6a416888dd3964d6aa3c44 |
| 出典メモ | uspto-grants-2008_02 |