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Potassium Carbonate → [1-(7-Cyclopropylmethyl-3-phenylxanthin-1-yl)methyl]dimethylphosphine Oxide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | (Chloromethyl)cyclopropane | HCID 80013 | — |
| 反応物 | [1-(3-Phenylxanthin-1-yl)methyl]dimethylphosphine Oxide | HCID 9818429 | — |
| 生成物 | [1-(7-Cyclopropylmethyl-3-phenylxanthin-1-yl)methyl]dimethylphosphine Oxide | HCID 19689179 | — |
反応手順
3.9 g (0.0123 mol) of [1-(3-phenylxanthin-1-yl)methyl]dimethylphosphine oxide (Example 70) were stirred at 70° C. for 6 hours with 1.33 g (0.0147 mol) of chloromethylcyclopropane and 2 g of potassium carbonate. The solution was filtered and concentrated, and the residue which remained was chromatographed on silica gel (eluent: ethyl acetate/methanol 10:1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05728686 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-81b4f491699b43439864ee808917472d |
| 出典メモ | uspto-grants-1998_03 |