4,4,4-Trifluoro-1-(3-fluorophenyl)butane-1,3-dione → HCID 67213091、化合物

反応式

[F:1][C:2]1[CH:3]=[C:4]([C:8](=O)[CH2:9][C:10](=O)[C:11]([F:14])([F:13])[F:12])[CH:5]=[CH:6][CH:7]=1.[NH2:17][C:18]1[C:22]([C:23]#[N:24])=[CH:21][NH:20][N:19]=1>>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[C:10]([C:11]([F:14])([F:13])[F:12])[N:19]3[N:20]=[CH:21][C:22]([C:23]#[N:24])=[C:18]3[N:17]=2)[CH:5]=[CH:6][CH:7]=1

参加物

反応物 2

HCID 431869184,4,4-Trifluoro-1-(3-fluorophenyl)butane-1,3-dione

HCID 178510443HCID 178510443、化合物

生成物 1

HCID 67213091HCID 67213091、化合物収率 46%

実験手順

Reaction of 1-(3-fluoro-phenyl)-4,4,4-trifluoro-butane-1,3-dione (234 mg, 1.0 mmol), prepared from commercially available 3-fluoro-acetophenone according to general procedure A, and 3-amino-4-cyano-pyrazole (108 mg, 1.0 mmol) according to general procedure B yielded the title compound as a light yellow solid (141 mg, 46%). MS (ISP) 306.9 [(M+H)+]; mp 199° C.

出典と根拠

ORDレコード: ord-ec83cb71386549b69b1f934f44a1c0c2
出典データセット: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07329662B2

反応ノート

読み込み中…

参加物