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3-amino-5-methyl-1H-pyrazole-4-carbonitrile → 2-Methyl-5-(4-trifluoromethyl-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-amino-5-methyl-1H-pyrazole-4-carbonitrile | HCID 227460 | — |
| 反応物 | 4,4,4-Trifluoro-1-(4-trifluoromethylphenyl)-1,3-butanedione | HCID 10859020 | — |
| 生成物 | 2-Methyl-5-(4-trifluoromethyl-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carbonitrile | HCID 86598658 | 63.2% |
反応手順
Reaction of 1-(4-trifluoromethyl-phenyl)-4,4,4-trifluoro-butane-1,3-dione (284 mg, 1.0 mmol), prepared from commercially available 4-trifluoromethyl-acetophenone according to general procedure A, and commercially available 3-amino-4-cyano-5-methyl-pyrazole (122 mg, 1.0 mmol) according to general procedure B yielded the title compound as a light yellow solid (234 mg, 63%). MS (ISP) 371.1 [(M+H)+]; mp 184° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07329662B2 |
| 出典データセット | uspto-grants-2008_02 |
| ORD ID | ord-30200895b3c6463abd85eb24ebeba7ff |
| 出典メモ | uspto-grants-2008_02 |